Senior Director, Translational Research, Protein Homeostasis TRC

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

The Protein Homeostasis Thematic Research Center (PH TRC) advances BMS’s protein degradation and homeostasis strategies from discovery into early clinical development to address tumor‑intrinsic vulnerabilities and resistance mechanisms—enabling action on targets previously considered undruggable. As the Brisbane-based Senior Director of Translational Research, you will provide strategic scientific and organizational leadership in a cross-functional, cross-site environment, setting translational vision and standards and shaping and executing end-to-end translational strategies across a portfolio of early programs (pre-IND through Phase 1).You will influence portfolio-level decisions and ensure integration of preclinical biology with clinical biomarker strategy to drive patient enrichment, proof-of-mechanism, and decision-grade data in first-in-human trials.

Reporting into PH TRC Translational leadership, this role operates in a highly matrixed, cross‑site environment, partnering closely with Discovery Biology, Translational Development, Precision Medicine, Informatics & Predictive Sciences, and Early Clinical Development. You will represent the translational function at enterprise‑level governance, regulatory interactions, and external scientific forums, while building and sustaining a high‑performing, globally connected translational organization.

Position Responsibilities

In the role as a Senior Director within Translational Research, the ideal candidate:

• Enterprise & Scientific Leadership: Define and drive end-to-end translational strategy across a portfolio of early programs (pre-IND through Phase 1), integrating preclinical biology with clinical biomarker planning to enable proof-of-mechanism, patient enrichment hypotheses, and portfolio-level decision making.
• Team Management: Lead and develop the Brisbane translational team, fostering scientific excellence, accountability, and career development in a collaborative, inclusive environment.
• Cross‑Functional Partnership: Drive alignment with Translational Development, Precision Medicine, Clinical Development, and Informatics & Predictive Sciences (IPS) to ensure seamless execution of biomarker plans and data interpretation.
• Assay Development & Validation: Oversee design, optimization, and validation of translational assays for clinical sample analysis, ensuring robustness, reproducibility, and compliance with quality systems.
• Governance & Representation: Represent translational research at senior internal governance bodies, external scientific meetings, and health authority interactions; provide senior translational leadership input to regulatory submissions and briefing materials.
• Innovation & Data Science: Champion the application of advanced analytics and AI/ML approaches to translational datasets (multi‑omics, digital pathology, longitudinal biomarker data) to accelerate hypothesis generation and signal detection.
• Operational Excellence: Ensure audit‑ready documentation, adherence to QMS standards, and continuous improvement initiatives to enhance efficiency and scientific rigor across workflows.

Experience

Basic Qualifications:

• Bachelor’s Degree
  • 15+ years of academic and / or industry experience

Or

• Master’s Degree
  • 12+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
  • 10+ years of academic and / or industry experience
• 8+ years of leadership experience

Preferred Qualifications:

Education & Experience:

• Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Oncology, Translational Sciences) with 12+ years of experience in translational research, including leadership roles in biotech or pharmaceutical settings.

Scientific Expertise:

• Deep understanding of biomarker strategy, assay development, and clinical sample analysis in early‑phase oncology trials.
• Proven track record of integrating preclinical and clinical data to inform dose selection and patient stratification.

Leadership & Collaboration:

• Proven ability to lead senior‑level teams and operate effectively in complex, global, matrixed organizations.
• Strong executive communication and influencing skills with internal governance bodies, regulators, and external stakeholders.

Technical & Analytical Skills:

• Familiarity with advanced analytics and AI/ML applications in translational research; experience leveraging computational tools for multi‑omics and biomarker data integration is highly desirable.

Quality & Compliance:

• Knowledge of GCP, QMS, and regulatory expectations for biomarker data in clinical development.

Behavioral Competencies:

• Strategic thinker with a results‑oriented mindset, adaptability to evolving priorities, and commitment to fostering an inclusive team culture.

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Brisbane - CA - US: $272,720 - $330,476


The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

​Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com. Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response. Inquiries related to the status of your application should be directed to Chat with Ripley.

R1600075 : Senior Director, Translational Research, Protein Homeostasis TRC