Senior Principal Scientist, Discovery Chemistry

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Job Summary

Accomplished medicinal chemist aiming to lead and contribute to the BMS portfolio as an integral member of the Global Discovery Chemistry (GDC) organization, based in San Diego

We are seeking a talented and highly motivated individual with a strong background in medicinal chemistry to join our Discovery and Development Sciences (D&DS) team in San Diego. The successful candidate will contribute and lead a team of scientists that engage in rational design of new agents for the potential treatment of diverse oncology indications. The individual will apply modern drug design principles to solve medicinal chemistry problems relevant to the Protein Homeostasis Thematic Research Center project portfolio. Furthermore, you will also collaborate with a broad group of scientists within the BMS Discovery and Development Sciences group to advance the projects from inception to IND.

Qualifications

• Ph.D. in synthetic organic chemistry with 6+ years pharmaceutical medicinal chemistry industrial experience (8+ years preferred) or
• M.S. in synthetic organic chemistry with 8+ years pharmaceutical medicinal chemistry industrial experience (10+ years preferred) or
• B.S. in synthetic organic chemistry with 10+ years pharmaceutical medicinal chemistry industrial experience (12+ years preferred)
• Previous experience supporting and advancing target protein degradation and/or antibody-drug conjugate programs is preferred.
• Demonstrated ability to contribute and advance drug discovery programs with strong proficiency in fundamental aspects of drug discovery are required
• Track record of innovation and impact on programs documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals is necessary (may include both successful advances and data-driven terminations)
• Strong working knowledge of protein-ligand interactions, ADME, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of AI/ML and computational predictive tools and models as well as visualization applications.
• High level of creativity and productivity with strong synthetic productivity, problem solving skills, synthetic methods, and reaction mechanisms are required
• Ability to champion chemistry efforts into new directions to achieve project milestones
• Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
• Proven leadership capability in cross-functional teams, either as project team leader or co-leader
• Proven track record of mentoring PhD and/or MSc/BSc-level scientists to high levels of productivity, whilst improving the skills and knowledge of direct reports through mentorship and focused development activities
• Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the R&ED organization

Fit with BMS Culture and Values

• Diversity and inclusion
• Strong team orientation; highly collaborative, both within internal San Diego group and across the broader GDC and D&DS organization.
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

San Diego - CA - US: $182,250 - $220,842


The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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